This book is a study of cooperative security efforts between the United States and Russia since the collapse of the Soviet Union. It undertakes an analysis of the Cooperative Threat Reduction (CTR) Programme and several other programmes established by different U.S. Departments. The CTR process demonstrates both, the achievements and limitations of the evolving new framework of interaction between the U.S. and Russia. This investigation is the first attempt to use the CTR process as a case study for U.S.-Russian strategic relations in the post-Cold War international security system. By answering the questions of why this process is prone to some persistent problems of implementation and why it was possible in the first place, it yields significant conclusions regarding the nature of U.S.-Russian relations, and the achievements as well as limitations in the bilateral relationship since the end of the Cold War.From Antagonism to Partnership contributes to the existing literature on cooperative threat reduction as a study linking CTR to the wider context of the opportunities, challenges and constraints determining the nature of post-Cold War relations between the U.S. and Russia.